Table 1.

Effect of guggulsterone on PC-3 cell cycle distribution

Treatment% Cells
G0-G1SG2-M
DMSO (control)57 ± 117 ± 122 ± 1
Guggulsterone (10 μmol/L)59 ± 116 ± 122 ± 2
Guggulsterone (20 μmol/L)61 ± 1*13 ± 1*23 ± 2
  • NOTE: Cells were treated with DMSO or desired concentrations of guggulsterone for 24 hours at 37°C. Both floating and attached cells were collected and processed for analysis of cell cycle distribution. Results are mean ± SE (n = 3). Similar results were observed in two independent experiments.

  • * P < 0.05, significantly different compared with control by one-way ANOVA followed by Dunnett's test.