Table 2.

Comparison of cytotoxicity of O5-methyl psorospermin with 9a and 9b

Cell lineOriginIC50 (μmol/L)
(±)-(2′R,3′R) O5-methyl psorospermin9a9b
8226/SMultiple myeloma0.0360.0950.200
HL60Acute promyelocytic leukemia0.0120.0370.076
HL60/AR (Adriamycin resistant)Acute promyelocytic leukemia0.0110.0450.110
K562Chronic myelogenous leukemia0.0360.0810.076
K562/R (daunorubicin resistant)Chronic myelogenous leukemia0.0240.0620.145
A2780Ovarian0.0630.1330.245
A2780/CP70Ovarian0.4730.6131.453
DU 145Prostate, brain metastasis0.3040.6850.751
LNCaPProstate, lymph node metastasis0.4600.6301.400
MiaPaCa-2Pancreas0.1800.5700.610