Comparison of cytotoxicity of O5-methyl psorospermin with 9a and 9b
| Cell line | Origin | IC50 (μmol/L) | ||||
|---|---|---|---|---|---|---|
| (±)-(2′R,3′R) O5-methyl psorospermin | 9a | 9b | ||||
| 8226/S | Multiple myeloma | 0.036 | 0.095 | 0.200 | ||
| HL60 | Acute promyelocytic leukemia | 0.012 | 0.037 | 0.076 | ||
| HL60/AR (Adriamycin resistant) | Acute promyelocytic leukemia | 0.011 | 0.045 | 0.110 | ||
| K562 | Chronic myelogenous leukemia | 0.036 | 0.081 | 0.076 | ||
| K562/R (daunorubicin resistant) | Chronic myelogenous leukemia | 0.024 | 0.062 | 0.145 | ||
| A2780 | Ovarian | 0.063 | 0.133 | 0.245 | ||
| A2780/CP70 | Ovarian | 0.473 | 0.613 | 1.453 | ||
| DU 145 | Prostate, brain metastasis | 0.304 | 0.685 | 0.751 | ||
| LNCaP | Prostate, lymph node metastasis | 0.460 | 0.630 | 1.400 | ||
| MiaPaCa-2 | Pancreas | 0.180 | 0.570 | 0.610 | ||