Table 1.

IC50 of (±)-(2′R,3′R) O5-methyl psorospermin in solid tumors, leukemias, and lymphomas

Cell lineOriginO5-methyl psorospermin (IC50, μmol/L)
Solid tumors
    A2780Ovarian0.063
    A2780/CP70 (cisplatin resistant)Ovarian0.473
    MCF-7Breast, adenocarcinoma0.610
    MCF-10ABreast normal mammary5.350
    DU-145Prostate, brain metastasis0.304
    LNCaPProstate, lymph node metastasis0.460
    PEAZ-1Prostate, primary0.160
    PC-3Prostate, adenocarcinoma, metastasis0.280
    PC-3NProstate, N-cadherin positive0.130
    MiaPaCa-3Pancreas0.180
    NCI-H82Small cell lung cancer0.067
Leukemias
    8226/SMultiple myeloma0.036
    HL60Acute promyelocytic leukemia0.012
    HL60/AR (Adriamycin resistant)Acute promyelocytic leukemia0.011
    K562Chronic myelogenous leukemia0.036
    K562/R (daunorubicin resistant)Chronic myelogenous leukemia0.024
Lymphomas
    U937Lymphoma (Non-Hodgkin's lymphoma)0.057
    GrantaMantle cell lymphoma0.002
    G4Mantle cell lymphoma0.002