Table 3.

Comparison of known human Eg5 mitotic arrest inhibitors

NSC No./NameStructureMitotic Arrest IC50, μmol/LNCI 60 Tumor Cell Line Screen GI50, mol/L*
CK0106023Embedded ImageND364 nmol/L
MonastrolEmbedded Image25 (50)ND
Terpendole EEmbedded ImageNDND
56817∼402.92e−6
169676122.97e−5
832650.71.31e−6
78206∼501.42e−5
59349ND2.19e−6
  • * Data taken from the NCI database. GI50 is 50% inhibition of growth averaged over 60 tumor cell lines.

  • Mean growth inhibitory activity of compound CK0106023 toward 12 human cell lines. Data taken from ref. 50.

  • HeLa cells treated with 15 μmol/L NSC 59349 were already dead after 8-hour incubation.