Table 2.

The effect of PGE₂ and PGE₂ analogues on rodent intestinal tumorigenesis

Model	PGE₂ Analogue	EP Receptor Activity	Weekly Dose^* (μg)	Duration (wk)	% Untreated Tumor Number	Change in Tumor Size
Apc^Min/+ mouse (63)	dmPGE₂ + 17-phenyl-trinor-PGE₂	EP2–EP4	180	1^†	83	↓
Apc^Min/+ mouse (63)	dmPGE₂ + 17-phenyl-trinor-PGE₂			1^†	83	↓	EP1, EP3	180
Apc^Min/+ mouse (65)	dmPGE₂	EP2–EP4	0.03	7	∼50	↓
Rat azoxymethane-induced colon carcinogenesis (64)	PGE₂^‡	EP1–EP4	100	25	280	↑

↵* All dosings were by i.p. injection apart from the study by Hansen-Petrik et al. (63), in which 10 μg of each analogue were given by daily gavage.
↵† 6 days.
↵‡ PGE₂ β-cyclodextrin clathrate.