Table 2.

Pharmacokinetic parameters of PX-866, PX-867, and PX-881

CompoundCmax (μg/mL)t1/2 (min)AUC (0→∞) (min μg/mL)Cl (mL/min/kg)Vd (L/kg)
PX-8661.9518.427.703609.61
PX-8670.2220.35.191,92556.3
PX-8810.603.328.31565.8
  • NOTE: Mice were administered PX-866, PX-867, and PX-881 i.v. at 10 mg/kg. The pharmacokinetic parameters are Cmax (maximum plasma concentration), t1/2 (half-life), AUC from time 0 minute to infinity, Cl (plasma clearance), and Vd (volume of distribution).