Table 4.

Summary IC50 (nmol/L) phospho-blot data from LoVo (Human Colon Tumor) cells exposed to CNQs

MEKMAPKSAPAKTEGF-RP-TYR
Class 1 Compound
    1a>1,000380>1,000>1,000>1,000>1,000
    1b>1,000300>1,000>1,000>1,000>1,000
Class 2 Compound
    2b80.01>1,000>1,000>1,000>1,000
    2and*ndndndndnd
  • NOTE: All IC50 data derived from densitometry done on Western blots (see Materials and Methods).

  • * nd, not done due to poor compound solubility.