Table 3.

Humlan tumor cell line growth inhibition by class 1 (1a, 1b) and class 2 (2a, 2b) CNQs

IC50 (nmol/L)
Cell LineOriginRas StatusFTI-276Class 1Class 1Class 2Class 2
1a1b2a2b
LoVoColonK-ras 13D100 ± 22400 ± 27380 ± 2215 ± 77 ± 3
HCT116ColonK-ras 13D50 ± 14>1,000900 ± 133900 ± 230450 ± 61
LNCapProstatewt (wild-type)>1,0001,000 ± 167>1,000600 ± 12150 ± 15
T24BladderH-ras 12V100 ± 13950 ± 141900 ± 168450 ± 70100 ± 26
MiaPacaPancreasK-ras 12C>1,000500 ± 49>1,000350 ± 75200 ± 90
BXPC3Pancreaswt>1,000500 ± 58410 ± 29300 ± 9040 ± 10
CaCo-2Colonwt>1,000>1,000>1,000>1,000>1,000