Table 2.

Specificity of class 1 (1a, 1b) and class 2 (2a, 2b) CNQs in kinase assays

KinaseClassCompoundIC50 (nmol/L)
Raf11a800
11b850
22a850
22b850
MEK111a7
11b6
22a5
22b1
EGFR11a700
11b700
22a700
22b700
MK211a>1,000
11b>1,000
22a>1,000
22b>1,000
Akt11a>1,000
11b>1,000
22a>1,000
22b>1,000
CDK411a>1,000
11b>1,000
22a>1,000
22b>1,000