Table 1.

Raf/MEK1/MAPK ELISA signal inhibition by various kinase inhibitors and CNQ compounds

CompoundIC50 (nmol/L)Comment
SKB-203580160Raf/p38 inhibitor
PD 980592,800MEK1 inhibitor
PP3300Lck inhibitor
EKI-5692,000EGFR inhibitor
Staurosporine3Generic kinase inhibitor
Olomoucine>10,000Serine/Threonine kinase inhibitor
Tyrphostin>10,000Tyrosine kinase inhibitor
Genistein>10,000Tyrosine kinase inhibitor
Lavendustin A>10,000Tyrosine kinase inhibitor
Apigenin>10,000Serine/Threonine kinase inhibitor
Wyeth CompoundsIC50 (nmol/L)Comment
1a5MEK1 inhibitor
1b6MEK1 inhibitor
2a5MEK1 inhibitor
2b1MEK1 inhibitor