Table 5.

Pharmacokinetic parameters of CYC202 and Purvalanol A in the different cassettes

CompoundCassetteAUClast
Clobs
Cmax
t1/2lz
tmax
Vss(obs)
(nm h)(ml/h)(nm)(h)(h)(ml)
CYC202A4,508374,1660.97043
CYC202B1,957851,9070.89068
CYC202C4,719353,5830.78037
CYC202F1,6351022,2720.6050
CYC202G4,530366,0471.53025
CYC202H2,777603,7060.55030
CYC202I2,198762,1940.51051
CYC202K4,182406,1821.33020
CYC202M5,070336,6640.57017
CYC202N6,475258,0130.71016
CYC202Q4,157406,808NEa0NE
CYC202R4,424386,323NE0NE
CYC202S3,704455,107NE0NE
CYC202T3,670455,382NE0NE
CYC202W2,994544,165NE0NE
CYC202Z3,222513,0350.83034
PUAbD5,789299,9440.42010
PUAE9,077186,6460.83019
PUAL3,353493,3071.01041
PUAO4,568374,9090.52023
PUAV4,723356,3541.22021
  • a NE, not estimated as too few time points were detectable.

  • b PUA, purvalanol A.