Table 4.

Pharmacokinetic parameters derived from the full data set and the limited sampling strategy (0.5, 2, 4, 6 h)

CompoundAdministrationCmaxAUClastVss(obs)ClobsAUCinf(obs)t1/2λz
(nm)(l/h)(l)(h)(nm h)(h)
bohemineall samples7,6752,8190.541.012,8971.27
LSS10,2462,8350.231.032,8440.92
olomoucineall samples6,2323,0180.671.083,0891.01
LSS7,0883,0910.431.073,1190.8
CYC202all samples11,37115,7880.240.1716,2851.38
LSS11,01520,1200.250.1320,8841.31
  • Note: LSS, limited sampling strategy.