Table 2.

Summary analytical and pharmacokinetics results

CompoundPharmacokinetic ratios relative to CYC202 or PUA
CodeaFWPurity (%)bAUCCmaxt1/2Vss
{AAA}368.5890.20.4
{AAB}340.4922121.8
{AAC}366.5990.50.20.63.2
{AAE}394.5820.60.6
{AAF}340.4920.61
{ABA}382.5880.30.2
{ABB}354.591NS
{ABC}380.5951.63
{ABE}408.6910.20.10.56.6
{ABF}354.5830.10.116.6
{ACA}370.56900.01
{ACB}342.41001.42.1
{ACC}368.41000.61.060.50.79
{ACD}382.5991TP
{ACE}396.51001TP
{ACF}342.4891TP
{ADA}394.5810.50.4
{ADB}366.51000.40.31.84.2
{ADC}392.5931.31.8
{ADE}420.684
{ADF}366.5941.53.2
{BAA}428.5920.71.8
{BAB}400.51000.20.4
{BAC}426.5950.30.3
{BAD}440.5951.31.250.40.5
{BAF}400.5811.10.31.61.4
{BBA}442.6850.91.3
{BBB}414.5840.10.1
{BBC}440.592NS
{BBD}454.695NSI
{BBE}468.6631.60.31.82.7
{BBF}414.5851.42.2
{BCA}430.5910.20.4
{BCB}402.5840.20.1
{BCC}428.5911.22
{BCF}402.5951TP
{BDA}454.61000.3
{BDB}426.5960.10.10.55.9
{BDC}452.6960.10.2
{BDD}466.687NSI
{BDE}480.61000.40.3
{BDF}426.5851.7210.5
{CAA}394.5910.10.1
{CAB}366.5891.32.30.72.9
{CAC}392.592NSI
{CAD}406.5881110.6
{CAE}420.6810.50.50.51.7
{CAF}366.5880.50.312.3
{CBA}408.6960.20.2
{CBB}380.5890.41.2
{CBC}406.59512
{CBD}420.6870.50.5
{CBE}434.6790.30.3
{CBF}380.5950.40.31.31.2
{CCA}396.5971.41.40.90.6
{CCB}368.491NSI
{CCC}394.5100NSI
{CCF}368.4920.60.6
{CDA}420.693
{CDB}392.5840.30.4
{CDC}418.5970.40.8
{CDD}432.684NS
{CDE}446.6760.60.60.62
{CDF}392.5970.10.1
{DAA}442.6830.20.2
{DAB}414.5991.11.30.8
{DAC}440.694NSI
{DAE}468.685
{DAF}414.5940.50.231.73.3
{DBA}456.6900.30.2
{DBB}428.58511.2
{DBC}454.690NSI
{DBE}482.696
{DBF}428.5860.80.8
{DCA}444.5971.42.1
{DCB}416.5991TP
{DCC}470.697NSI
{DCC}442.599NS
{DCD}456.610022.10.54.1
{DCF}416.5940.50.3
{DDA}468.6940.10.4
{DDB}440.6990.80.61.72.1
{DDC}466.699NSI
{DDD}480.6940.50.3
{DDF}440.699NS
{EAA}391.5910.10.1
{EAB}363.5760.40.2
{EAC}389.598NSI
{EAD}403.5800.10.1
{EAE}417.6940.40.70.91.4
{EAF}363.5910.80.8
{EBA}405.5920.30.3
{EBB}377.5722.43
{EBC}403.5942.45
{EBE}431.6820.70.7
{EBF}377.5811TP
{ECA}393.5990.50.8
{ECB}365.481NSI
{ECC}391.51000.70.7
{ECD}405.577NSI
{ECE}419.592NSI
{ECF}365.49611
{EDA}417.6850.81.71.71.7
{EDB}389.581NSI
{EDC}415.5870.20.3
{EDE}443.6931.32.20.70.3
{EDF}389.588NSI
  • Note: PUA, purvalanol A; FW, formula weight; NS, not soluble; NSI, no signal; 1TP, one time point detectable. No value indicates that parameter cannot be calculated.

  • a Refer to Fig. 2 for explanation of compound coding system.

  • b Derived from integration (λ = 210 nm) of RP-HPLC chromatograms.