Table 1.

Effects of NOS inhibitors on C5aAP-stimulated VP changes

Vascular leakage (μl blood/g skin)
Without C5aAPTreated with C5aAP
PBS control41.0 ± 3.793.1 ± 28.9a
l-NAME (10 mg/kg)48.7 ± 6.572.3 ± 23.8
AG (20 mg/kg)41.1 ± 1.853.9 ± 13.1b
  • Note: Mice were treated i.v. with l-NAME (0.2 mg/mouse) or AG (0.4 mg/mouse) 5 min before 125I-IgG administration. Each value represents the mean ± SD of four mice.