Table 2.

Function and expression of identified proteins

ProteinFunctionCaco-2 / HRT-18 expression
UCH-L1Involved in the translational processing of pro-ubiquitin gene products as well as in the release of ubiquitin from tagged proteinsExpressed in Caco-2
CLIC 1Belongs to the superfamily of GST, is a vital component of cellular detoxification4.3/1.0
GSTPDemonstrates various functional activities, such as regulation of stress kinases, cell protection from cytotoxic and radiation damage, and participation in carcinogenesis47.2/1.0
QPRTaseRegulates tryptophane biosynthesis and probably participates in the ordering of membrane permeabzation5.1/1.0
Microtubule-associated protein RP/EB family member 1Participates in regulating microtubule dynamics and chromosome segregation2.8/1.0
Annexin A3Involved in membrane trafficking, fusion, and permeabilization2.0/1.0
Galectin-3Implicated in cell growth, differentiation, adhesion, RNA progression, and apoptosis4.1/1.0
PKCI-1Although it was originally thought to inhibit PKC its actual physiologic function is not known3.4/1.0
E-FABPModulation of mitosis, cell growth, differentiation, PKC, activation, sequestration, or removal of cytotoxic drugsExpressed in HRT-18
HSP 27Inhibits actin polymerization, prevents pro-caspase-9 and pro-caspase-3 activation, and regulates detoxification mechanisms mediated by the action of glutathione1.0/4.5
Profilin IG-actin sequestration and inhibition actin polymerization1.0/3.2
PpasePlays an important role in energy metabolism, providing a thermodynamic pull for many biosynthetic reactions. Very little is known about the enzyme from mammalian tissues1.0/3.3
PSATParticipates in cell metabolism and cellular replication1.0/20.9
PSA 7Participates in positive or negative regulation of transcriptional factors in cancer cells1.0/5
  • NOTE: Differences in protein expression are indicated as ratio between means of protein expression in Caco-2 and HRT-18 cells. For key to abbreviations, see Table 1.