Table 1.

Sensitivity of U87 and HT100 cells treated with rhEPO, AG490, and rhEPO + AG490 to ionizing radiation and cisplatin

Cell Line TreatmentControl*rhEPO (30 units/mL)*AG490 (μmol/L)*rhEPO + AG490*
U87, ionizing radiation (Gy)7.4 (±0.38)10.1 (±0.45)6.9 (±0.43)7.3 (±0.41)
U87, cisplatin (μmol/L)14.0 (±0.67)28.6 (±0.58)12.1 (±0.41)13.8 (±0.51)
HT100, ionizing radiation (Gy)4.1 (±0.27)5.0 (±0.25)4.0 (±0.36)4.1 (±0.32)
HT100, cisplatin (μmol/L)6.7 (±0.31)15.7 (±0.39)6.4 (±0.28)7.0 (±0.37)
  • NOTE: Values represent the radiation dose or drug concentration that produces 50% cytotoxicity. All values are the means of three independent experiments (±SE).

  • * P < 0.01 with 7.4 versus 10.1 Gy and 4.1 versus 5.0 Gy of radiation, respectively. Likewise, P < 0.01 with 14.0 versus 28.6 mol/L and 6.7 versus 15.7 μmol/L of cisplatin, respectively.