Table 3.

Antitumor efficacy in the breast (MDA-MB-435) human tumor xenograft

CompoundsDose/scheduleTGD (d)% T/C
ZD6126200 mg/kg q6d × 3868
MX-5815110 mg/kg b.i.d. × 5 d865
MX-5827640 mg/kg b.i.d. × 5 d475
MX-7674710 mg/kg (q1d × 5) 3 wk1258
MX-11621415 mg/kg (q1d × 5) 3 wk1555
MX-11640745 mg/kg (q1d × 5) 3 wk1643
MX-1263031 mg/kg (q1d × 5) 3 wk675