Selected ErbB-targeted monoclonal antibodies
| Monoclonal Antibody | Type | Target | Stage of Development |
|---|---|---|---|
| Cetuximab (Erbitux, C225) | Human/mouse chimeric antibody | EGFR | Approved for colon cancer |
| Panitumumab (ABX-EGF) | Fully human antibody | EGFR | Phase II |
| Trastuzumab (Herceptin) | Humanized antibody | HER-2 | Approved for HER-2-positive breast cancer |
| Pertuzumab (2C4) | Humanized antibody | HER-2 | Phase II |