Table 1.

Selected ErbB-targeted monoclonal antibodies

Monoclonal AntibodyTypeTargetStage of Development
Cetuximab (Erbitux, C225)Human/mouse chimeric antibodyEGFRApproved for colon cancer
Panitumumab (ABX-EGF)Fully human antibodyEGFRPhase II
Trastuzumab (Herceptin)Humanized antibodyHER-2Approved for HER-2-positive breast cancer
Pertuzumab (2C4)Humanized antibodyHER-2Phase II