Table 3

Tumor development in iNOS knockout mice

TargetResultiNOS effect on neoplasia (↑/↓)aRef. no.
Intestine
Apcmin/+ iNOS−/−↓Adenoma formation16
Apcmin/+ iNOS−/+
Apcmin/+ iNOS−/−↑Adenoma formation19
Lung
 iNOS−/− mice treated with urethane↓Tumor formation89
  • a iNOS expression has promoting (↑) or inhibitory (↓) effect on neoplasia.