Table 1

Changes in iNOS expression/activity during tumor development in animals

Target species (carcinogen)NOS expression/activityiNOS effect on neoplasia (↑/↓)aRef. no.
Colon
 Rat (AOM)b↑Activity colonic mucosa9
 Rat (AOM)↑Activity colonic mucosa8
 Rat (AOM)↑Expression adenocarcinoma87
 Rat (AOM)↑Expression dysplastic ACF, adenoma, adenocarcinoma11
Oral cavity
 Hamster (DMBA)↑Expression hyperplasia, dysplasia, squamous cell carcinoma49 and 50
Esophagus
 Rat (NMBA)↑Expression preneoplastic tissue, papilloma54
 Rat (esophageal-duodenal astomosis, iron)↑Expression esophagus55
Lung
 Rat (cigarette smoke)↑Expression terminal bronchiole lesions88
 Mouse (urethane)↑Expression tumors89
  • a iNOS expression has promoting (↑) or inhibitory (↓) effect on neoplasia.

  • b AOM, azoxymethane; DMBA, 7,12-dimethylbenz (a) anthracene; NMBA, N-nitroso-N-methylbenzylamine.