Properties of colcemid and vinblastine resistant cell lines
| Cell line | Two-dimensional gel change (new spot) | Drug sensitivity | Tubulin assembly (% of total tubulin) | ||
|---|---|---|---|---|---|
| Paclitaxel | Colcemid | ||||
| Wild-type | No change | Sa | S | 39 | |
| Tax 5-6 | α1 Basic shift | R | SS | 25 (P <0.01)b | |
| Cmd4 | β1 Basic shift | SSc | Rc | 50c | |
| CV 1-1 | β1 Basic shift | SS | R | 54 (P < 0.01) | |
| CV 7-1 | β1 Lower molecular weight | S | R | 47 (P< 0.05) | |
| CV 4-4 | β1 Acidic shift | SS | R | 50 (P< 0.01) | |
| CV 8-1 | No change | SS | R | 48 (P <0.02) | |
| CV 1-5 | α1 Acidic shift | SS | R | 51 (P <0.01) | |
| CV 2-8 | α1 Basic shift | SS | R | 47 (P <0.02) | |
| CV 2-3 | No change | SS | R | 50 (P < 0.01) | |
| VV 3-2 | α1 Acidic shift | SS | R | 48 (P <0.01) | |