Table 2

Percentage change in tumor volume with docetaxel and docetaxel/flavopiridol combinations

Treatment 1Time intervalTreatment 2No. of animals% change in tumor volume on day 17aStatistical significance between Doc vs. Doc/Flavo
Controln.a.bn.a.18+1850 ± 99%
Flavocn.a.n.a.18+1392 ± 89%
Docn.a.n.a.18+394 ± 26%
Doc0 h →Flavo18+183 ± 12%P > 0.05 (NS)d
Doc3 h →Flavo6−1 ± 9%P = 0.002
Doc7 h →Flavo18−18 ± 4%P = 6 × 10−4
Doc16 h →Flavo12+56 ± 10%P = 0.019
Flavo7 h →Doc5+395 ± 75%P > 0.05 (NS)
  • a % change (+, increase; −, decrease) in mean tumor volume on day 17 compared with mean tumor volume on day 3, ±SE.

  • b n.a., not applicable.

  • c Flavo, flavopiridol; Doc, docetaxel.

  • d NS, nonsignificant.