Table 1

Examples of developed near-infrared protease probes

Tested probes along with known peptide cleavage sequence are listed.

These proteases are involved in a wide range of pathologies.

SpecificityEnzyme substrate
Cathepsin BK↓K, R↓R
Cathepsin DPIC(Et)F↓F
MMP-2P(L/Q)G↓ (I/L)AG
Cathepsin KGGPRGLPG
Prostate-specific antigenHSSKLQ↓
Herpes simplex virus proteaseLVLA*SSSFGY
HIV proteaseGVSQNY*PIVG
Cytomegalovirus proteaseGVVQA·SCRLA
ThrombindFPipR
Caspase-3DEVD
Interleukin 1 β converting enzymeGWEHD*G