Table 4

Effect of tRA 98006 on anthracycline cytotoxicity in MCF7 cells

Note: MCF7/S, MCF7/R, MCF7/MRP1-10, and MCF7 AdVp3000 cells were treated with doxorubicin, daunorubicin, or mitoxantrone for 72 h in the absence and presence of tRA 98006 at 0.1, 1, and 10 μm. Results are expressed as RMFs. Experimental values are representative of at least triplicate experiments over which the SE was calculated.

DoxorubicinDaunorubicinMitoxantrone
0.1 μm1 μm10 μm0.1 μm1 μm10 μm0.1 μm1 μm10 μm
MCF7/S2.76 ± 0.71.3 ± 0.21.3 ± 0.071.6 ± 0.142.1 ± 0.62.1 ± 1.11.8 ± 0.33.1 ± 1.52.5 ± 0.5
MCF7/R4.62 ± 0.715 ± 320.1 ± 15.2 ± 0.915 ± 5.713.1 ± 0.63.6 ± 0.76 ± 0.819.74 ± 2.6
MCF7/MRP1-101.6 ± 0.34.9 ± 0.074.61 ± 0.21.5 ± 0.44.7 ± 0.216.99 ± 0.13.7 ± 1.719.8 ± 0.624.02 ± 0.8
MCF7 AdVp30001.04 ± 0.061.6 ± 0.32.98 ± 0.161.2 ± 0.181.3 ± 0.21.67 ± 0.40.9 ± 0.080.97 ± 0.090.96 ± 0.17