Table 3

RMFs of broad-spectrum tRAs on mitoxantrone cytotoxicity in resistant cell lines

Note: 8226/Dox6, HL60/ADR, and 8226/MR20 cells were treated with mitoxantrone for 96 h in the absence and presence of tRAs 98006, 98007, 99018, or 99020 at 0.1, 1, and 10 μm. Results are expressed as RMFs calculated as (IC50 mitoxantrone) / (IC50 mitoxantrone + tRA). Experimental values are representative of at least triplicate experiments over which the SE was calculated.

tRA 98006tRA 98007tRA 99018tRA 99020
0.1 μm1 μm10 μm0.1 μm1 μm10 μm0.1 μm1 μm10 μm0.1 μm1 μm10 μm
8226/Dox63.11 ± 1.2913.8 ± 3.213.9 ± 4.22.78 ± 0.311.8 ± 2.714.5 ± 2.11.53 ± 0.66.05 ± 0.97.2 ± 1.81.12 ± 0.42.7 ± 0.179.8 ± 3.6
HL60/ADR1.09 ± 0.141.78 ± 0.112.2 ± 0.171.16 ± 0.091.21 ± 0.121.4 ± 0.21.05 ± 0.061.25 ± 0.261.11 ± 0.110.97 ± 0.041.34 ± 0.181.61 ± 0.37
8226/MR202.04 ± 0.622.7 ± 5.919 ± 5.32.83 ± 0.930 ± 5.731.8 ± 1.41.59 ± 0.069.78 ± 6.85.2 ± 0.91.25 ± 0.0415.9 ± 5.350.7 ± 15.2