Table 2

tRAs with activity against Pgp

Note: The structures are the tRAs selected for testing against other MDRs based on activity in modulating Pgp. The IC50 reduction represents the percent decrease in the IC50 of paclitaxel in the presence of 0.1 μm tRA in the MDA435/LCC6mdr1 cell line, which overexpresses Pgp.

Table 2