Table 1.

Effect of SU11271, SU11274, and SU11606 on enzymatic activity of Met and other kinases

EnzymaticAssaysSU11271 IC50m)SU11274 IC50m)SU11606 IC50m)
Met0.040.010.17
Ron5.64.02.5
PDGFRβ>20>20>20
FGFR10.58.51.8
EGFR>100>100>100
FLK-11.281.250.18
CDK2>20>10>20