Table 1.

Cancer cell line IC50s on bpV treatment

Note: IC50s of cell lines exposed to bpV[Phen] and bpV[Me2Phen]. Cytotoxicity was determined using the SRB assay and a continuous 96-h exposure to bpVs. Micromolar IC50s represent the mean of those determined in at least two independent experiments with four replicates per concentration in each experiment.

TypeLinePhen
Me2Phen
TypeLinePhen
Me2Phen


IC50m)
IC50m)


IC50m)
IC50m)
LeukemiaCem2.700.80OvarianOVCAR32.000.84
LeukemiaK5621.250.30OvarianOVCAR42.700.31
LeukemiaMolt 41.950.50Renal786-01.120.63
LeukemiaNB4ND0.58RenalA4981.050.75
NSC LungA5491.800.37RenalACHN2.000.6
NSC LungEKVX1.401.05RenalCaKi-10.450.34
LungLL21.700.30RenalUO31ND0.27
ColonHCT116 p21+/+ND0.81ProstatePC32.240.35
ColonHCT116 p21−/−ND0.70ProstateDU1451.240.28
ColonHCT116 p53+/+ND0.52BreastMCF-72.950.84
ColonHCT116 p53−/−ND0.48BreastNIH ADR1.230.24
ColonSW6202.610.78BreastMB 231ND0.42
CNSSF295ND0.49BreastMB 468ND0.62
CNS
SNB75
7.5
1.48
Head and Neck
SCCA
1.00
0.30