Table 2.

Down-regulation of bcl-2 protein expression in G3139 truncation mutants

Oligonucleotide% Inhibition of bcl-2 proteina
3′ Truncation mutations
5′-TCT CCC AGC GTG OGC CAT-3′84
TCT CCC AGC GTG OGC CA84
TCT CCC AGC GTG OGC C37
5′ Truncation mutations
5′-TCT CCC AGC GTG OGC CAT-3′90
CT CCC AGC GTG OGC CAT85
T CCC AGC GTG OGC CAT84
CCC AGC GTG OGC CAT85
C AGC GTG OGC CAT85
GC GTG OGC CAT68
GTG OGC CAT16
  • a As determined by Western blotting and laser scanning densitometry as described in text.