Table 2

IC50a (ng/ml) of BCRP-transfected PA317 cells

PA317PA/WTPA/V12MPA/Q141KPA/Δ315-6
SN-382.598983055
Mitoxantrone0.0600.580.630.250.42
Topotecan17>200>200100190
  • a IC50s (drug dose causing 50% inhibition of cell growth) were determined from cell growth curves in each experiment.