Table 3

Comparison of gross toxicity in LNCaP tumor-bearing nude mice treated with desacetyl-vinblastine or vinblastine-conjugate

Experimental protocols are described in the legend to Table 2. Data represent average weights of mice surviving at the end of therapy.

Vehicle Controls
 Average wgt. loss (%)a14
desacetyl-Vinblastine
 Drug doses (μmol/kg)b0.260.390.52
 Average wgt. loss (%)131415
 Number mice deadc137
Vinblastine-conjugate
 Drug doses (μmol/kg)1.22.44.99.215.321.4
 Average wgt. loss (%)14107527
 Number mice dead000000
  • a Percentage of decrease from pretreatment weights.

  • b Drugs were administered once a day for 5 consecutive days.

  • c Ten mice/group at the start of study.