Table 4.

Effects of the IC50 concentration of CP248 on stabilized MT in 9L cells

The 9L cells were treated with the IC50 concentration of CP248 for 6 h, fixed, and stained for stable MT with the SG antibody, as described in “Materials and Methods” and Figs. 3, C and D. A positive cell was defined as any cell that expressed 12 or more SG-stained MT or very bright foci of SG. Bright foci of SG represent a large amount of stabilized MT in a concentrated region of the cell. This experiment was repeated twice with similar results. A minimum of 150 cells were scored in each experiment.

Drug% of cells positiveSD