Table 1.

Inhibition of cell proliferation by sulindac sulfone (exisulind) and derivatives in a series of glioma cell lines

Cell proliferation was determined by tritiated thymidine incorporation, as described in “Materials and Methods.” IC50 values, calculated from a concentration curve, indicate the concentrations of the drugs that caused a 50% inhibition of tritiated thymidine incorporation when compared with a control culture treated only with the vehicle, 0.1% DMSO. Data are the mean values from two separate experiments in which all of the assays were done in triplicate. Repeat assays differed by less than 10%.

Cell lineIC50m)
Rat glioma cell lines
Human glioma cell lines
NIH mouse fibroblasts