Table 1.

Inhibition of cell proliferation by sulindac sulfone (exisulind) and derivatives in a series of glioma cell lines

Cell proliferation was determined by tritiated thymidine incorporation, as described in “Materials and Methods.” IC50 values, calculated from a concentration curve, indicate the concentrations of the drugs that caused a 50% inhibition of tritiated thymidine incorporation when compared with a control culture treated only with the vehicle, 0.1% DMSO. Data are the mean values from two separate experiments in which all of the assays were done in triplicate. Repeat assays differed by less than 10%.

Cell lineIC50m)
ExisulindCP461CP248
Rat glioma cell lines
 9L1791.140.078
 C61681.080.068
 F98960.7250.075
 D741371.020.064
Human glioma cell lines
 U871401.430.083
 U1381401.190.070
 U3731450.980.077
 A1721351.170.078
 GB12400.80.069
 GB21801.350.073
 GB31721.040.067
 GB41451.090.088
NIH mouse fibroblasts
 3T32001.50.108