Table 4

Sequence variants found in class I β-tubulin in chimpanzee, gorilla, orangutan, and human (including number of heterozygous individuals and geographic location for humans)

Genomic positiona (location within gene)ChimpanzeeGorillaOrangutanHumanNo. of heterozygotesContinentb
132 (5′UTR)CCTTnacnaTT
160 (5′UTR)GGCCnanaCC
196 (5′UTR)GGGAAAGG
227 (5′UTR)AAGGAAAA
357 (intron 1)CCCCGGCC
387 (intron 1)AAAAGGAA
2128 (intron 1)GGTTnanaGG
2138 (intron 1)AAGGnanaGG
2153 (intron 1)AAAAAAAT12Af, As, Oc
2183 (intron 1)CCCCTTCC
2193 (intron 1)CCCCGGCC
2280 (exon 2)CCCTCCCC
2359 (intron 2)AAAACCAA
2372 (intron 2)TTGGTTTT
2384 (intron 2)GGAAGGGG
2394 (intron 2)TTTTCCTdelT1Af
2395 (intron 2)CCCCTTCC
2404 (intron 2)TTTTCCTT
2406 (intron 2)AAAATTAA
2429 (intron 2)TTCCCCCC
2430 (intron 2)insTCinsTC
2439 (intron 2)CCTTCCCC
2450 (intron 2)AATTAAAA
2476 (intron 2)AAAAAAGG
2703 (intron 3)CCCCCCCT2Eu
2723 (intron 3)TTAATTTT
2754 (intron 3)AAGGGGGG
2805 (intron 3)AAAATTAA
2823 (intron 3)dTTTTTTTC16Af, As, Oc
2901 (intron 3)AAAAGGAA
2915 (intron 3)GGGGAAGG
2928 (intron 3)GGGGCCGG
2986 (intron 3)CCCCTTCC
3082 (exon 4)GGGGCCGG
3113 (exon 4)CCCCTTCC
3202 (exon 4)CCTTCCCC
3250 (exon 4)GGAAGGGG
3259 (exon 4)CCCCCTCC
3289 (exon 4)TTCCCCCC
3310 (exon 4)TTTTCCTT
3376 (exon 4)dGGGGGGGA7As, Oc
3427 (exon 4)TTTTCCTT
3835 (exon 4)TTCCTTTT
3925 (exon 4)dCCCCCCCT1As
4012 (exon 4)CCCCTTCC
4115 (3′UTR)dGGGGGGGT8As, Oc
4116 (3′UTR)CCCCCCCT8As, Oc
4130 (3′UTR)CCTTCCCC
4174 (3′UTR)CCCCdelCdelCCC
4179 (3′UTR)7G7G7G7G7G7G7–9G7–9G47Global
4184 (3′UTR)GGGAGGGG
  • a Nucleotide positions are given in relation to clone m40 (GenBank accession number J00314).

  • b Af, Africa; As, Asia; Oc, Oceania.

  • c na, not available because orangutan could be amplified only with a different set of primers.

  • d Human DNA variant at CpG or CpNG site.