Table 1

Therapy of human pancreatic carcinoma growing in the pancreas of nude mice

One million Colo-357-L3.6pl cells were injected into the pancreas of nude mice. Seven days later, the mice were randomly assigned to four treatment groups of 10 mice each. The first group received twice-weekly i.p. injections of 5% DMSO in HBSS as control. The second, third, and fourth groups received twice-weekly i.p. injections of LY294002 at 10, 25, and 100 mg/kg. All mice were sacrificed after 4 weeks of treatment.

Treatment groupsTumor weight in milligrams Mean ± SDLymph nodes metastasesLiver metastasesPeritoneal carcinomatosisBody weight in grams Mean ± SD
BeforeAfter
Control921.7 ± 266.810/109/104/1026.54 ± 2.6226.45 ± 2.36
LY294002 10 mg/kg826.1 ± 221.59/98/93/926.13 ± 2.4527.98 ± 2.54
LY294002 25 mg/kg740.8 ± 214.69/108/103/1026.87 ± 2.9829.08 ± 3.04
LY294002 100 mg/kg615.3 ± 184.5a8/105/101/1026.64 ± 2.4329.04 ± 2.89
  • a P < 0.005 versus control.