Table 1

Drug resistance profile of A549.EpoB40 cells.

IC50s were determined after 72 h of incubation with the indicated drugs. The IC50 of A549.EpoB40 cells was divided by the IC50 of A549 cells to indicate the fold decrease or increase in drug sensitivity.

CompoundIC50 (nm)Fold
A549A549.EpoB40
Epo B0.96 ± 0.1191.50 ± 3.8895
Epo A1.89 ± 0.26136.91 ± 4.7172
Taxol3.12 ± 0.3667.96 ± 15.4022
Taxotere1.34 ± 0.3916.87 ± 3.9113
Discoa7.68 ± 0.6416.60 ± 2.542
VBL2.31 ± 0.081.26 ± 0.470.5
CLC16.86 ± 0.6310.24 ± 1.030.6
  • a Disco, discodermolide; VBL, vinblastine; CLC, colchicine.