Table 1

MVA-m5T4 does alter fertility

A. Inoculation with MVA-m5T4 does not effect fertility of C57BL/6 micea
10 day study
30 day study60 day study
MVA- m5T4MVA- LacZPBSMVA- m5T4MVA- m5T4
No. of pregnancies4/54/53/54/55/5
No. live births2430182233
Average litter size67.565.56.6
B. Inoculation with MVA-m5T4 does not effect fertility of BALB/c mice or the health of their pupsb
10 day study
45 day study
MVA-m5T4MVA-LacZPBSMVA-m5T4
No. of pregnancies5/54/54/54/4
No. live births30232224
Average litter size65.755.56
Ratio F:M13:1114:511:1115:9
Average weights10.4 g11.2 g10.1 g11.4 g
  • a C57BL/6 mice were inoculated with MVA-m5T4, MAV-LacZ, or PBS at 0, 21, and 42 days; the mice were then mated at day 10 after last inoculation. MVA-m5T4 groups were also mated at days 30 and 60 after last inoculation.

  • b BALB/c mice were inoculated with MVA-m5T4, MAV-LacZ, or PBS at 0, 21, and 42 days; the mice were then mated at day 10 after last inoculation. An MVA-m5T4 group was also mated at 45 days after last inoculation.