Table 1.

X chromosome genes whose expression levels are significantly correlated with carboplatin or cisplatin sensitivity from a meta-analysis in the CEU and YRI samples

Affymetrix
Combined CEU and YRICEUYRI
meta P valuesmeta q valuesP valuesq values
Gene nameTranscript cluster IDCarboplatinCisplatinCarboplatinCisplatinCarboplatinCisplatinCarboplatinCisplatin
CD99L2a40257711.70E-084.20E-092.73E-069.02E-076.23E-042.37E-061.24E-067.55E-05
GPR174a39826124.05E-077.01E-063.25E-057.54E-041.78E-051.15E-031.22E-033.91E-04
STSa39676896.29E-062.85E-052.69E-041.53E-038.89E-068.16E-054.50E-022.48E-02
DLG3a39806436.70E-065.50E-042.69E-041.31E-021.11E-037.34E-023.85E-046.88E-04
MID1IP1a39740982.24E-051.12E-057.19E-048.00E-041.35E-011.36E-021.16E-055.42E-05
CLIC240277693.40E-054.24E-039.11E-045.06E-022.60E-052.07E-039.39E-022.38E-01
GRPR39700241.00E-048.04E-032.30E-036.66E-021.03E-021.26E-027.67E-048.10E-02
TMEM164a39870291.19E-041.75E-032.39E-032.35E-021.06E-032.29E-038.92E-037.96E-02
ACSL4a40178103.89E-042.64E-046.94E-037.43E-034.27E-046.12E-048.08E-023.69E-02
MAP3K15a40018505.44E-041.39E-047.35E-035.99E-031.97E-012.74E-022.53E-044.10E-04
FAM3Aa40273875.37E-049.10E-047.35E-031.78E-021.58E-016.52E-023.11E-041.35E-03
WWC339683975.49E-043.28E-027.35E-031.43E-015.21E-048.38E-029.67E-026.26E-02
CLCN5a39772999.02E-048.41E-041.04E-021.78E-021.57E-026.82E-035.54E-031.18E-02
CDKL539706428.49E-046.05E-021.04E-021.86E-012.55E-023.04E-013.19E-033.61E-02
PJA140114641.18E-036.54E-031.26E-026.52E-022.60E-042.87E-024.50E-012.81E-02
CTPS2a40008391.73E-031.71E-041.40E-026.13E-039.71E-024.78E-021.86E-032.94E-04
ATP6AP2a39745561.46E-031.07E-031.40E-021.83E-022.18E-028.03E-036.83E-031.32E-02
CNKSR239712191.72E-031.95E-021.40E-021.22E-015.34E-023.36E-013.34E-038.46E-03
MED1239807581.65E-033.64E-021.40E-021.51E-012.44E-041.18E-026.97E-015.04E-01
GDI139964041.74E-031.38E-011.40E-022.90E-013.68E-038.71E-024.92E-023.52E-01
SLC9A740068412.65E-034.92E-022.03E-021.75E-011.61E-018.77E-011.80E-039.74E-03
MAGEH139787603.25E-036.15E-022.38E-021.86E-014.99E-013.98E-017.32E-042.81E-02
GPC440223705.00E-038.06E-033.50E-026.66E-021.56E-021.35E-023.81E-027.59E-02
TSC22D3a40173815.84E-031.11E-033.87E-021.83E-022.54E-022.28E-012.79E-024.79E-04
EDA2Ra40110966.02E-033.03E-033.87E-023.83E-021.12E-037.24E-046.51E-014.64E-01
PIM240076176.61E-032.86E-024.08E-021.43E-018.22E-011.41E-019.91E-043.16E-02
PDZD1140116377.11E-031.48E-014.23E-022.97E-016.13E-023.29E-011.44E-021.03E-01
CXorf2140038957.65E-032.83E-014.39E-023.88E-012.63E-038.27E-023.66E-019.73E-01
OFD139694558.62E-037.52E-034.53E-026.66E-022.42E-011.50E-014.56E-036.28E-03
CFP40071648.26E-031.56E-014.53E-022.99E-011.75E-035.47E-026.01E-016.58E-01
LOC17008239693968.75E-031.72E-014.53E-023.03E-016.34E-017.81E-011.77E-035.26E-02
PIGA40005121.10E-022.76E-045.04E-027.43E-032.10E-021.79E-036.95E-021.33E-02
GLA40157632.27E-021.52E-037.36E-022.34E-022.45E-021.67E-031.39E-019.33E-02
PGK139824621.10E-011.67E-031.91E-012.35E-024.09E-022.50E-045.67E-016.89E-01

Note: Bold indicates that the gene expression level is correlated with sensitivity to both platinating agents (q value < 0.05) from a meta-analysis using the Affymetrix exon array data and is correlated with sensitivity to both platinating agents (P < 0.05) from a meta-analysis (in the combined CEU, YRI and ASN data) using the Illumina array.

Abbreviations: CEU, Caucasian; YRI, Yoruba people from Ibadan, Nigeria; ASN, Asian; NA, not available.

  • aRepresents the 14 genes whose expression levels are significantly correlated with both carboplatin and cisplatin sensitivity (q value < 0.05) after a meta-analysis in the combined CEU and YRI samples, based on Affymetrix exon array data.