Table 4.

Pharmacodynamic parameters (INR) following oral administration of a single dose of warfarin 20 mg (monotherapy) or in combination with patupilone 10 mg/m2 (n = 16)

ParametersWarfarin aloneWarfarin + patupilone
INRmax, INR3.13 ± 1.93 (62%)3.79 ± 3.70 (98%)
AUCINR, INR h282 ± 121 (43%)283 ± 111 (39%)
Ratio (comedication/monotherapy) of geometric means (90% CI)
INRmax1.07 (0.80–1.43)
AUCINR1.03 (0.93–1.15)
  • aArithmetic mean ± SD (percentage coefficient of variation).