Table 2.

Chemotherapeutic effect of intravesical silibinin on histopathologic changes in Sprague-Dawley rat bladders of different groups

GroupNo. of rats sacrificedNormal (%)Hyperplasia, or atypia/dysplasia (%)Superficial bladder cancer (%)Muscle invasive bladder cancer (%)
Control1010000
MNU2107 (33)9 (43)5 (24)
MNU + DMSO2407 (29)12 (50)5 (21)
MNU + SB-20022010 (45)9 (41)3 (14)
MNU + SB-400a241 (4)19 (79)3 (13)1 (4)
SB-4001513 (87)2 (13)00
DMSO + saline1413 (93)1 (7)00

SB, silibinin. MNU, N-methyl-N-nitrosourea.

  • aSignificantly different from the MNU or MNU + DMSO group (P < 0.05).