Table 1.

Chemopreventive effect of intravesical silibinin on histopathologic changes in Sprague-Dawley rat bladders of different groups

GroupNo. of rats sacrificedNormal (%)Hyperplasia, or atypia/dysplasia (%)Superficial bladder cancer (%)Muscle invasive bladder cancer (%)
Control1010000
MNU2409 (37.5)9 (37.5)6 (25)
MNU + DMSO2308 (35)10 (43)5 (22)
MNU + SB-200a24017 (71)6 (25)1 (4)
MNU + SB-400a,b232 (9)17 (74)4 (17)0
SB-4001413 (93)1 (7)00
DMSO + saline1412 (86)2 (14)00

SB, silibinin. MNU, N-methyl-N-nitrosourea.

  • aThe observed differences for histopathologic change in MNU + SB-200 and MNU + SB-400 groups versus the MNU or MNU + DMSO group were statistically significant with P < 0.05.

  • bSignificantly different from the MNU + SB-200 group (P < 0.05).