Table 1.

Chemopreventive effect of intravesical silibinin on histopathologic changes in Sprague-Dawley rat bladders of different groups

Group	No. of rats sacrificed	Normal (%)	Hyperplasia, or atypia/dysplasia (%)	Superficial bladder cancer (%)	Muscle invasive bladder cancer (%)
Control	10	10	0	0	0
MNU	24	0	9 (37.5)	9 (37.5)	6 (25)
MNU + DMSO	23	0	8 (35)	10 (43)	5 (22)
MNU + SB-200^a	24	0	17 (71)	6 (25)	1 (4)
MNU + SB-400^a,b	23	2 (9)	17 (74)	4 (17)	0
SB-400	14	13 (93)	1 (7)	0	0
DMSO + saline	14	12 (86)	2 (14)	0	0

SB, silibinin. MNU, N-methyl-N-nitrosourea.

↵^aThe observed differences for histopathologic change in MNU + SB-200 and MNU + SB-400 groups versus the MNU or MNU + DMSO group were statistically significant with P < 0.05.
↵^bSignificantly different from the MNU + SB-200 group (P < 0.05).