RT Journal Article
SR Electronic
T1 Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy
JF Molecular Cancer Therapeutics
JO Mol Cancer Ther
FD American Association for Cancer Research
SP 2103
OP 2109
DO 10.1158/1535-7163.MCT-09-0282
VO 8
IS 8
A1 Wang, Yingqun
YR 2009
UL http://mct.aacrjournals.org/content/8/8/2103.abstract
AB The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/β-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar cell polarity (PCP) signaling in cancer progression, invasion and metastasis, and angiogenesis. This review describes the PCP signaling pathway and its ever-expanding components and modulators, highlights the most recent studies that provide insight into the link between PCP signaling and cancer, and, finally, proposes a model by which PCP signaling may promote cancer development. This review underscores the emerging theme that deregulated PCP signaling contributes to tumorigenesis, providing new potential targets for cancer therapy. [Mol Cancer Ther 2009;8(8):2103–9]