Exploiting arginine auxotrophy with pegylated arginine deiminase (ADI-PEG20) to sensitize pancreatic cancer to radiotherapy via metabolic dysregulation

Pankaj K Singh; Amit A Deorukhkar; Bhanu P Venkatesulu; Xiaolin Li; Ramesh Tailor; John S. Bomalaski; Sunil Krishnan

doi:10.1158/1535-7163.MCT-18-0708

Research Article

Exploiting arginine auxotrophy with pegylated arginine deiminase (ADI-PEG20) to sensitize pancreatic cancer to radiotherapy via metabolic dysregulation

Pankaj K Singh, Amit A Deorukhkar, Bhanu P Venkatesulu, Xiaolin Li, Ramesh Tailor, John S. Bomalaski and Sunil Krishnan

Pankaj K Singh

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

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Amit A Deorukhkar

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

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Bhanu P Venkatesulu

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

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Xiaolin Li

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

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Ramesh Tailor

2Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

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John S. Bomalaski

3Medical Affairs, Polaris Group (United States)

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Sunil Krishnan

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

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For correspondence: skrishnan@mdanderson.org

DOI: 10.1158/1535-7163.MCT-18-0708

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Supplementary Data

Figure S1 - Experimental Plan
Figure S2 - MTS assay and clonogenic
Figure S3 - RPPA data
Figure S4 - BPI colocalization
Figure S5 - Ki67 and VEGF
Figure S6 - SiRNA
Figure S7 - Cell cycle

Published OnlineFirst August 8, 2019
doi: 10.1158/1535-7163.MCT-18-0708

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Exploiting arginine auxotrophy with pegylated arginine deiminase (ADI-PEG20) to sensitize pancreatic cancer to radiotherapy via metabolic dysregulation

Pankaj K Singh, Amit A Deorukhkar, Bhanu P Venkatesulu, Xiaolin Li, Ramesh Tailor, John S. Bomalaski and Sunil Krishnan

Mol Cancer Ther August 8 2019 DOI: 10.1158/1535-7163.MCT-18-0708

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Exploiting arginine auxotrophy with pegylated arginine deiminase (ADI-PEG20) to sensitize pancreatic cancer to radiotherapy via metabolic dysregulation