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More articles from Research Articles: Therapeutics

Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH₂-terminal kinase pathways
Chunrong Yu, Bret B. Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E. Kay, Christopher A. Carter, Lewis R. Roberts, Scott H. Kaufmann, Alex A. Adjei

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2378-2387; DOI: 10.1158/1535-7163.MCT-06-0235
Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1
Giuliana Cassinelli, Cinzia Lanzi, Giovanna Petrangolini, Monica Tortoreto, Graziella Pratesi, Giuditta Cuccuru, Diletta Laccabue, Rosanna Supino, Sara Belluco, Enrica Favini, Anna Poletti, Franco Zunino

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2388-2397; DOI: 10.1158/1535-7163.MCT-06-0245
Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice
Chandramu Chetty, Praveen Bhoopathi, Pushpa Joseph, Subramanyam Chittivelu, Jasti S. Rao, Sajani Lakka

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2289-2299; DOI: 10.1158/1535-7163.MCT-06-0169
A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells
Alison J. Butt, Caroline G. Roberts, Alan A. Seawright, Peter B. Oelrichs, John K. MacLeod, Tracy Y.E. Liaw, Maria Kavallaris, Tiffany J. Somers-Edgar, Gillian M. Lehrbach, Colin K. Watts, Robert L. Sutherland

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2300-2309; DOI: 10.1158/1535-7163.MCT-06-0170
Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells
Umasundari Sivaprasad, Tarek Abbas, Anindya Dutta

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2310-2316; DOI: 10.1158/1535-7163.MCT-06-0175
Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors
Ann Beliën, Stefanie De Schepper, Wim Floren, Boud Janssens, Ann Mariën, Peter King, Jacky Van Dun, Luc Andries, Jan Voeten, Luc Bijnens, Michel Janicot, Janine Arts

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2317-2323; DOI: 10.1158/1535-7163.MCT-06-0112
1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator–activated receptor–dependent and independent pathways
Ping Lei, Maen Abdelrahim, Stephen Safe

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2324-2336; DOI: 10.1158/1535-7163.MCT-06-0184
Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis
Roy Blum, Jasmine Jacob-Hirsch, Gideon Rechavi, Yoel Kloog

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2337-2347; DOI: 10.1158/1535-7163.MCT-06-0193
Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton
Marcel N.A. Bijman, Geerten P. van Nieuw Amerongen, Nancy Laurens, Victor W.M. van Hinsbergh, Epie Boven

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2348-2357; DOI: 10.1158/1535-7163.MCT-06-0242
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
Eveline Barbieri, Parth Mehta, Zaowen Chen, Linna Zhang, Andrew Slack, Stacey Berg, Jason M. Shohet

Molecular Cancer Therapeutics Sep 2006, 5 (9) 2358-2365; DOI: 10.1158/1535-7163.MCT-06-0305

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