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More articles from Large Molecule Therapeutics

Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti–PD-L1 Immunotherapy
Bin Yi, Hao Cheng, Dorota Wyczechowska, Qingzhao Yu, Li Li, Augusto C. Ochoa, Adam I. Riker, Yaguang Xi

Molecular Cancer Therapeutics Jul 2021, 20 (7) 1295-1304; DOI: 10.1158/1535-7163.MCT-20-0934
PCA062, a P-cadherin Targeting Antibody–Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin–expressing Malignancies
Qing Sheng, Joseph A. D'Alessio, Daniel L. Menezes, Christopher Karim, Yan Tang, Angela Tam, Suzanna Clark, Chi Ying, Anu Connor, Keith G. Mansfield, Jean-Michel Rondeau, Majid Ghoddusi, Felipe C. Geyer, Jane Gu, Margaret E. McLaughlin, Rick Newcombe, GiNell Elliot, William R. Tschantz, Sylvie Lehmann, Christie P. Fanton, Kathy Miller, Thomas Huber, Katherine G. Rendahl, Ursula Jeffry, Nancy K. Pryer, Emma Lees, Paul Kwon, Judith A. Abraham, Jason S. Damiano, Tinya J. Abrams

Molecular Cancer Therapeutics Jul 2021, 20 (7) 1270-1282; DOI: 10.1158/1535-7163.MCT-20-0708
Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells
Mariko Ishibashi, Junichi Yamamoto, Takumi Ito, Hiroshi Handa, Mika Sunakawa-Kii, Koiti Inokuchi, Rimpei Morita, Hideto Tamura

Molecular Cancer Therapeutics Jul 2021, 20 (7) 1283-1294; DOI: 10.1158/1535-7163.MCT-20-0246
Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy
Nils Ludwig, Łukasz Wieteska, Cynthia S. Hinck, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Richard J. Bauer, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside

Molecular Cancer Therapeutics Jun 2021, 20 (6) 1102-1111; DOI: 10.1158/1535-7163.MCT-20-0944
Obinutuzumab in Combination with Chemotherapy Enhances Direct Cell Death in CD20-Positive Obinutuzumab-resistant Non-Hodgkin Lymphoma Cells
Takaaki Fujimura, Yoriko Yamashita-Kashima, Natsumi Kawasaki, Shigeki Yoshiura, Naoki Harada, Yasushi Yoshimura

Molecular Cancer Therapeutics Jun 2021, 20 (6) 1133-1141; DOI: 10.1158/1535-7163.MCT-20-0864
A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
Mirim Hong, Youngki Yoo, Miyoung Kim, Ju Yeon Kim, Jeong Seok Cha, Myung Kyung Choi, Uijin Kim, Kyungyong Kim, Youngsoo Sohn, Donggoo Bae, Hyun-Soo Cho, Seung-Beom Hong

Molecular Cancer Therapeutics Jun 2021, 20 (6) 1142-1152; DOI: 10.1158/1535-7163.MCT-20-0907
Calicheamicin Antibody–Drug Conjugates with Improved Properties
Breanna S. Vollmar, Chris Frantz, Melissa M. Schutten, Fiona Zhong, Geoffrey del Rosario, Mary Ann T. Go, Shang-Fan Yu, Douglas D. Leipold, Amrita V. Kamath, Carl Ng, Keyang Xu, Josefa dela Cruz-Chuh, Katherine R. Kozak, Jinhua Chen, Zijin Xu, John Wai, Pragya Adhikari, Hans K. Erickson, Peter S. Dragovich, Andrew G. Polson, Thomas H. Pillow

Molecular Cancer Therapeutics Jun 2021, 20 (6) 1112-1120; DOI: 10.1158/1535-7163.MCT-20-0035
Preclinical Studies of OBI-999: A Novel Globo H–Targeting Antibody–Drug Conjugate
Ming-Chen Yang, Chi-Sheng Shia, Wan-Fen Li, Chun-Chung Wang, I-Ju Chen, Teng-Yi Huang, Yu-Jung Chen, Hui-Wen Chang, Chi-Huan Lu, Yueh-Chin Wu, Nan-Hsuan Wang, Jiann-Shiun Lai, Cheng-Der Yu, Ming-Tain Lai

Molecular Cancer Therapeutics Jun 2021, 20 (6) 1121-1132; DOI: 10.1158/1535-7163.MCT-20-0763
A Novel Antibody–IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis
Riccardo Corbellari, Marco Stringhini, Jaqueline Mock, Tiziano Ongaro, Alessandra Villa, Dario Neri, Roberto De Luca

Molecular Cancer Therapeutics May 2021, 20 (5) 859-871; DOI: 10.1158/1535-7163.MCT-20-0853
Dolaflexin: A Novel Antibody–Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect
Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, Mao Yin, Joshua D. Thomas, Susan M. Clardy, Patrick R. Conlon, Cheri A. Stevenson, Alex Uttard, LiuLiang Qin, Dmitry R. Gumerov, Elena Ter-Ovanesyan, Charlie Bu, Alex J. Johnson, Venu R. Gurijala, Dennis McGillicuddy, Michael J. DeVit, Laura L. Poling, Marina Protopopova, Ling Xu, Qingxiu Zhang, Peter U. Park, Donald A. Bergstrom, Timothy B. Lowinger

Molecular Cancer Therapeutics May 2021, 20 (5) 885-895; DOI: 10.1158/1535-7163.MCT-20-0166

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