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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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Interferon regulatory factor-1 (IRF1) can function as a tumor suppressor in breast cancer by regulating the balance of prosurvival and proapoptotic factors. Loss of IRF1 is an important characteristic of breast cancer cells that have acquired resistance to antiestrogen therapy, a phenotype that often develops in estrogen receptor-α positive (ER+) breast cancers. Interferon gamma (IFNγ), a type II interferon, can rescue IRF1 expression in antiestrogen-resistant breast cancer cells and restore their sensitivity to antiestrogen-mediated apoptosis. For details, see article by Ning and colleagues on page 1274.

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Molecular Cancer Therapeutics: 9 (5)
May 2010
Volume 9, Issue 5
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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