ABT-263 is an inhibitor of the Bcl-2 family members Bcl-2, Bcl-x_L, and Bcl-w. Genes that are predictive for sensitivity to ABT-263, as identified by genomic expression profiling, are connected to key Bcl-2 family members as shown in the analysis of the signature genes by Ingenuity Pathways Analysis. In this network, genes that are colored in pink have higher expression in resistant cell lines, while genes colored in green have higher expression in sensitive cell lines. For details, see article by Tahir and colleagues on page 545.