Table of Contents

Research Articles

• Research Articles

  2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin Axis

  Suman Kambhampati, Snigdha Banerjee, Kakali Dhar, Smita Mehta, Inamul Haque, Gopal Dhar, Monami Majumder, Gibanananda Ray, Peter J. Vanveldhuizen and Sushanta K. Banerjee

  Mol Cancer Ther March 1 2010 9 (3) 523-534; DOI:10.1158/1535-7163.MCT-09-0845

  
  
• Research Articles

  Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma

  Eisuke Kobayashi, Mari Masuda, Robert Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi, Hideo Morioka, Yoshiaki Toyama, Setsuo Hirohashi, Akira Kawai and Tesshi Yamada

  Mol Cancer Ther March 1 2010 9 (3) 535-544; DOI:10.1158/1535-7163.MCT-09-0774

  
  
• Research Articles

  Identification of Expression Signatures Predictive of Sensitivity to the Bcl-2 Family Member Inhibitor ABT-263 in Small Cell Lung Carcinoma and Leukemia/Lymphoma Cell Lines

  Stephen K. Tahir, John Wass, Mary K. Joseph, Viswanath Devanarayan, Paul Hessler, Haichao Zhang, Steve W. Elmore, Paul E. Kroeger, Christin Tse, Saul H. Rosenberg and Mark G. Anderson

  Mol Cancer Ther March 1 2010 9 (3) 545-557; DOI:10.1158/1535-7163.MCT-09-0651

  
  
• Research Articles

  The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G₂-M Checkpoint

  Zhihua Jiang, ShunQian Jin, Jack C. Yalowich, Kevin D. Brown and Baskaran Rajasekaran

  Mol Cancer Ther March 1 2010 9 (3) 558-568; DOI:10.1158/1535-7163.MCT-09-0627

  
  
• Research Articles

  Proanthocyanidins Inhibit In vitro and In vivo Growth of Human Non–Small Cell Lung Cancer Cells by Inhibiting the Prostaglandin E₂ and Prostaglandin E₂ Receptors

  Som D. Sharma, Syed M. Meeran and Santosh K. Katiyar

  Mol Cancer Ther March 1 2010 9 (3) 569-580; DOI:10.1158/1535-7163.MCT-09-0638

  
  
• Research Articles

  Association of Polymorphisms in AKT1 and EGFR with Clinical Outcome and Toxicity in Non–Small Cell Lung Cancer Patients Treated with Gefitinib

  Elisa Giovannetti, Paolo A. Zucali, Godefridus J. Peters, Filippo Cortesi, Armida D'Incecco, Egbert F. Smit, Alfredo Falcone, Jacobus A. Burgers, Armando Santoro, Romano Danesi, Giuseppe Giaccone and Carmelo Tibaldi

  Mol Cancer Ther March 1 2010 9 (3) 581-593; DOI:10.1158/1535-7163.MCT-09-0665

  
  
• Research Articles

  Anacardic Acid Inhibits Estrogen Receptor α–DNA Binding and Reduces Target Gene Transcription and Breast Cancer Cell Proliferation

  David J. Schultz, Nalinie S. Wickramasinghe, Margarita M. Ivanova, Susan M. Isaacs, Susan M. Dougherty, Yoannis Imbert-Fernandez, Albert R. Cunningham, Chunyuan Chen and Carolyn M. Klinge

  Mol Cancer Ther March 1 2010 9 (3) 594-605; DOI:10.1158/1535-7163.MCT-09-0978

  
  
• Research Articles

  The Prolyl Isomerase Pin1 Enhances HER-2 Expression and Cellular Transformation via Its Interaction with Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase 1

  Prem Khanal, Gwang Mo Namgoong, Bong Seok Kang, Eun-Rhan Woo and Hong Seok Choi

  Mol Cancer Ther March 1 2010 9 (3) 606-616; DOI:10.1158/1535-7163.MCT-09-0560

  
  
• Research Articles

  Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells

  Murielle Mimeault, Sonny L. Johansson, Jean-Pierre Henichart, Patrick Depreux and Surinder K. Batra

  Mol Cancer Ther March 1 2010 9 (3) 617-630; DOI:10.1158/1535-7163.MCT-09-1013

  
  
• Research Articles

  Antiangiogenic Activities of 2,5-Dimethyl-Celecoxib on the Tumor Vasculature

  Jenilyn J. Virrey, Zhi Liu, Hee-Yeon Cho, Adel Kardosh, Encouse B. Golden, Stan G. Louie, Kevin J. Gaffney, Nicos A. Petasis, Axel H. Schönthal, Thomas C. Chen and Florence M. Hofman

  Mol Cancer Ther March 1 2010 9 (3) 631-641; DOI:10.1158/1535-7163.MCT-09-0652

  
  
• Research Articles

  SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

  Veronica Novotny-Diermayr, Kanda Sangthongpitag, Chang Yong Hu, Xiaofeng Wu, Nina Sausgruber, Pauline Yeo, Gediminas Greicius, Sven Pettersson, Ai Leng Liang, Yung Kiang Loh, Zahid Bonday, Kee Chuan Goh, Hannes Hentze, Stefan Hart, Haishan Wang, Kantharaj Ethirajulu and Jeanette Marjorie Wood

  Mol Cancer Ther March 1 2010 9 (3) 642-652; DOI:10.1158/1535-7163.MCT-09-0689

  
  
• Research Articles

  ABT-869 Inhibits the Proliferation of Ewing Sarcoma Cells and Suppresses Platelet-Derived Growth Factor Receptor β and c-KIT Signaling Pathways

  Alan K. Ikeda, Dejah R. Judelson, Noah Federman, Keith B. Glaser, Elliot M. Landaw, Christopher T. Denny and Kathleen M. Sakamoto

  Mol Cancer Ther March 1 2010 9 (3) 653-660; DOI:10.1158/1535-7163.MCT-09-0812

  
  
• Research Articles

  The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells

  Martin Grundy, Claire Seedhouse, Shilli Shang, Jaineeta Richardson, Nigel Russell and Monica Pallis

  Mol Cancer Ther March 1 2010 9 (3) 661-672; DOI:10.1158/1535-7163.MCT-09-1144

  
  
• Research Articles

  Efficacy of PHA-848125, a Cyclin-Dependent Kinase Inhibitor, on the K-Ras^G12DLA2 Lung Adenocarcinoma Transgenic Mouse Model: Evaluation by Multimodality Imaging

  Anna Degrassi, Micaela Russo, Cristina Nanni, Veronica Patton, Rachele Alzani, Anna M. Giusti, Stefano Fanti, Marina Ciomei, Enrico Pesenti and Gemma Texido

  Mol Cancer Ther March 1 2010 9 (3) 673-681; DOI:10.1158/1535-7163.MCT-09-0726

  
  
• Research Articles

  Doxorubicin Resistance in a Novel In vitro Model of Human Pleomorphic Liposarcoma Associated with Alternative Lengthening of Telomeres

  Marcy A. Mitchell, Jay E. Johnson, Kara Pascarelli, Neil Beeharry, Maria Chiourea, Sarantis Gagos, Dina Lev, Margaret von Mehren, David Kipling and Dominique Broccoli

  Mol Cancer Ther March 1 2010 9 (3) 682-692; DOI:10.1158/1535-7163.MCT-09-0705

  
  
• Research Articles

  Interactions of the p53 Protein Family in Cellular Stress Response in Gastrointestinal Tumors

  Anna E. Vilgelm, Mary K. Washington, Jinxiong Wei, Heidi Chen, Vladimir S. Prassolov and Alexander I. Zaika

  Mol Cancer Ther March 1 2010 9 (3) 693-705; DOI:10.1158/1535-7163.MCT-09-0912

  
  
• Research Articles

  Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor

  Emmanuelle J. Meuillet, Song Zuohe, Robert Lemos, Nathan Ihle, John Kingston, Ryan Watkins, Sylvestor A. Moses, Shuxing Zhang, Lei Du-Cuny, Roy Herbst, Jörg J. Jacoby, Li Li Zhou, Ali M. Ahad, Eugene A. Mash, D. Lynn Kirkpatrick and Garth Powis

  Mol Cancer Ther March 1 2010 9 (3) 706-717; DOI:10.1158/1535-7163.MCT-09-0985

  
  
• Research Articles

  Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca²⁺ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

  Betty Y.K. Law, Mingfu Wang, Dik-Lung Ma, Fawaz Al-Mousa, Francesco Michelangeli, Suk-Hang Cheng, Margaret H.L. Ng, Ka-Fai To, Anthony Y.F. Mok, Rebecca Y.Y. Ko, Sze Kui Lam, Feng Chen, Chi-Ming Che, Pauline Chiu and Ben C.B. Ko

  Mol Cancer Ther March 1 2010 9 (3) 718-730; DOI:10.1158/1535-7163.MCT-09-0700

  
  
• Research Articles

  Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

  Elyssa M. Rubin, Yi Guo, Khoa Tu, Jun Xie, Xiaolin Zi and Bang H. Hoang

  Mol Cancer Ther March 1 2010 9 (3) 731-741; DOI:10.1158/1535-7163.MCT-09-0147

  
  
• Research Articles

  Sorafenib Inhibits STAT3 Activation to Enhance TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

  Shengbing Huang and Frank A. Sinicrope

  Mol Cancer Ther March 1 2010 9 (3) 742-750; DOI:10.1158/1535-7163.MCT-09-1004

  
  
• Research Articles

  Phase I Combination of Sorafenib and Erlotinib Therapy in Solid Tumors: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation from an Expansion Cohort

  Miguel Quintela-Fandino, Christophe Le Tourneau, Ignacio Duran, Eric X. Chen, Lisa Wang, Ming Tsao, Bizhan Bandarchi-Chamkhaleh, Nhu-Ann Pham, Trevor Do, Martha MacLean, Rakesh Nayyar, Michael W. Tusche, Ur Metser, John J. Wright, Tak W. Mak and Lillian L. Siu

  Mol Cancer Ther March 1 2010 9 (3) 751-760; DOI:10.1158/1535-7163.MCT-09-0868

  
  
• Research Articles

  IFN-β Restricts Tumor Growth and Sensitizes Alveolar Rhabdomyosarcoma to Ionizing Radiation

  Thomas L. Sims, Mackenzie McGee, Regan F. Williams, Adrianne L. Myers, Lorraine Tracey, J. Blair Hamner, Catherine Ng, Jianrong Wu, M. Waleed Gaber, Beth McCarville, Amit C. Nathwani and Andrew M. Davidoff

  Mol Cancer Ther March 1 2010 9 (3) 761-771; DOI:10.1158/1535-7163.MCT-09-0800