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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther March 1 2010 9 (3) 521-521;

Research Articles

  • Research Articles
    2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin Axis
    Suman Kambhampati, Snigdha Banerjee, Kakali Dhar, Smita Mehta, Inamul Haque, Gopal Dhar, Monami Majumder, Gibanananda Ray, Peter J. Vanveldhuizen and Sushanta K. Banerjee
    Mol Cancer Ther March 1 2010 9 (3) 523-534; DOI:10.1158/1535-7163.MCT-09-0845

  • Research Articles
    Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma
    Eisuke Kobayashi, Mari Masuda, Robert Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi, Hideo Morioka, Yoshiaki Toyama, Setsuo Hirohashi, Akira Kawai and Tesshi Yamada
    Mol Cancer Ther March 1 2010 9 (3) 535-544; DOI:10.1158/1535-7163.MCT-09-0774

  • Research Articles
    Identification of Expression Signatures Predictive of Sensitivity to the Bcl-2 Family Member Inhibitor ABT-263 in Small Cell Lung Carcinoma and Leukemia/Lymphoma Cell Lines
    Stephen K. Tahir, John Wass, Mary K. Joseph, Viswanath Devanarayan, Paul Hessler, Haichao Zhang, Steve W. Elmore, Paul E. Kroeger, Christin Tse, Saul H. Rosenberg and Mark G. Anderson
    Mol Cancer Ther March 1 2010 9 (3) 545-557; DOI:10.1158/1535-7163.MCT-09-0651

  • Research Articles
    The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G2-M Checkpoint
    Zhihua Jiang, ShunQian Jin, Jack C. Yalowich, Kevin D. Brown and Baskaran Rajasekaran
    Mol Cancer Ther March 1 2010 9 (3) 558-568; DOI:10.1158/1535-7163.MCT-09-0627

  • Research Articles
    Proanthocyanidins Inhibit In vitro and In vivo Growth of Human Non–Small Cell Lung Cancer Cells by Inhibiting the Prostaglandin E2 and Prostaglandin E2 Receptors
    Som D. Sharma, Syed M. Meeran and Santosh K. Katiyar
    Mol Cancer Ther March 1 2010 9 (3) 569-580; DOI:10.1158/1535-7163.MCT-09-0638

  • Research Articles
    Association of Polymorphisms in AKT1 and EGFR with Clinical Outcome and Toxicity in Non–Small Cell Lung Cancer Patients Treated with Gefitinib
    Elisa Giovannetti, Paolo A. Zucali, Godefridus J. Peters, Filippo Cortesi, Armida D'Incecco, Egbert F. Smit, Alfredo Falcone, Jacobus A. Burgers, Armando Santoro, Romano Danesi, Giuseppe Giaccone and Carmelo Tibaldi
    Mol Cancer Ther March 1 2010 9 (3) 581-593; DOI:10.1158/1535-7163.MCT-09-0665

  • Research Articles
    Anacardic Acid Inhibits Estrogen Receptor α–DNA Binding and Reduces Target Gene Transcription and Breast Cancer Cell Proliferation
    David J. Schultz, Nalinie S. Wickramasinghe, Margarita M. Ivanova, Susan M. Isaacs, Susan M. Dougherty, Yoannis Imbert-Fernandez, Albert R. Cunningham, Chunyuan Chen and Carolyn M. Klinge
    Mol Cancer Ther March 1 2010 9 (3) 594-605; DOI:10.1158/1535-7163.MCT-09-0978

  • Research Articles
    The Prolyl Isomerase Pin1 Enhances HER-2 Expression and Cellular Transformation via Its Interaction with Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase 1
    Prem Khanal, Gwang Mo Namgoong, Bong Seok Kang, Eun-Rhan Woo and Hong Seok Choi
    Mol Cancer Ther March 1 2010 9 (3) 606-616; DOI:10.1158/1535-7163.MCT-09-0560

  • Research Articles
    Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells
    Murielle Mimeault, Sonny L. Johansson, Jean-Pierre Henichart, Patrick Depreux and Surinder K. Batra
    Mol Cancer Ther March 1 2010 9 (3) 617-630; DOI:10.1158/1535-7163.MCT-09-1013

  • Research Articles
    Antiangiogenic Activities of 2,5-Dimethyl-Celecoxib on the Tumor Vasculature
    Jenilyn J. Virrey, Zhi Liu, Hee-Yeon Cho, Adel Kardosh, Encouse B. Golden, Stan G. Louie, Kevin J. Gaffney, Nicos A. Petasis, Axel H. Schönthal, Thomas C. Chen and Florence M. Hofman
    Mol Cancer Ther March 1 2010 9 (3) 631-641; DOI:10.1158/1535-7163.MCT-09-0652

  • Research Articles
    SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
    Veronica Novotny-Diermayr, Kanda Sangthongpitag, Chang Yong Hu, Xiaofeng Wu, Nina Sausgruber, Pauline Yeo, Gediminas Greicius, Sven Pettersson, Ai Leng Liang, Yung Kiang Loh, Zahid Bonday, Kee Chuan Goh, Hannes Hentze, Stefan Hart, Haishan Wang, Kantharaj Ethirajulu and Jeanette Marjorie Wood
    Mol Cancer Ther March 1 2010 9 (3) 642-652; DOI:10.1158/1535-7163.MCT-09-0689

  • Research Articles
    ABT-869 Inhibits the Proliferation of Ewing Sarcoma Cells and Suppresses Platelet-Derived Growth Factor Receptor β and c-KIT Signaling Pathways
    Alan K. Ikeda, Dejah R. Judelson, Noah Federman, Keith B. Glaser, Elliot M. Landaw, Christopher T. Denny and Kathleen M. Sakamoto
    Mol Cancer Ther March 1 2010 9 (3) 653-660; DOI:10.1158/1535-7163.MCT-09-0812

  • Research Articles
    The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells
    Martin Grundy, Claire Seedhouse, Shilli Shang, Jaineeta Richardson, Nigel Russell and Monica Pallis
    Mol Cancer Ther March 1 2010 9 (3) 661-672; DOI:10.1158/1535-7163.MCT-09-1144

  • Research Articles
    Efficacy of PHA-848125, a Cyclin-Dependent Kinase Inhibitor, on the K-RasG12DLA2 Lung Adenocarcinoma Transgenic Mouse Model: Evaluation by Multimodality Imaging
    Anna Degrassi, Micaela Russo, Cristina Nanni, Veronica Patton, Rachele Alzani, Anna M. Giusti, Stefano Fanti, Marina Ciomei, Enrico Pesenti and Gemma Texido
    Mol Cancer Ther March 1 2010 9 (3) 673-681; DOI:10.1158/1535-7163.MCT-09-0726

  • Research Articles
    Doxorubicin Resistance in a Novel In vitro Model of Human Pleomorphic Liposarcoma Associated with Alternative Lengthening of Telomeres
    Marcy A. Mitchell, Jay E. Johnson, Kara Pascarelli, Neil Beeharry, Maria Chiourea, Sarantis Gagos, Dina Lev, Margaret von Mehren, David Kipling and Dominique Broccoli
    Mol Cancer Ther March 1 2010 9 (3) 682-692; DOI:10.1158/1535-7163.MCT-09-0705

  • Research Articles
    Interactions of the p53 Protein Family in Cellular Stress Response in Gastrointestinal Tumors
    Anna E. Vilgelm, Mary K. Washington, Jinxiong Wei, Heidi Chen, Vladimir S. Prassolov and Alexander I. Zaika
    Mol Cancer Ther March 1 2010 9 (3) 693-705; DOI:10.1158/1535-7163.MCT-09-0912

  • Research Articles
    Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor
    Emmanuelle J. Meuillet, Song Zuohe, Robert Lemos, Nathan Ihle, John Kingston, Ryan Watkins, Sylvestor A. Moses, Shuxing Zhang, Lei Du-Cuny, Roy Herbst, Jörg J. Jacoby, Li Li Zhou, Ali M. Ahad, Eugene A. Mash, D. Lynn Kirkpatrick and Garth Powis
    Mol Cancer Ther March 1 2010 9 (3) 706-717; DOI:10.1158/1535-7163.MCT-09-0985

  • Research Articles
    Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis
    Betty Y.K. Law, Mingfu Wang, Dik-Lung Ma, Fawaz Al-Mousa, Francesco Michelangeli, Suk-Hang Cheng, Margaret H.L. Ng, Ka-Fai To, Anthony Y.F. Mok, Rebecca Y.Y. Ko, Sze Kui Lam, Feng Chen, Chi-Ming Che, Pauline Chiu and Ben C.B. Ko
    Mol Cancer Ther March 1 2010 9 (3) 718-730; DOI:10.1158/1535-7163.MCT-09-0700

  • Research Articles
    Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma
    Elyssa M. Rubin, Yi Guo, Khoa Tu, Jun Xie, Xiaolin Zi and Bang H. Hoang
    Mol Cancer Ther March 1 2010 9 (3) 731-741; DOI:10.1158/1535-7163.MCT-09-0147

  • Research Articles
    Sorafenib Inhibits STAT3 Activation to Enhance TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells
    Shengbing Huang and Frank A. Sinicrope
    Mol Cancer Ther March 1 2010 9 (3) 742-750; DOI:10.1158/1535-7163.MCT-09-1004

  • Research Articles
    Phase I Combination of Sorafenib and Erlotinib Therapy in Solid Tumors: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation from an Expansion Cohort
    Miguel Quintela-Fandino, Christophe Le Tourneau, Ignacio Duran, Eric X. Chen, Lisa Wang, Ming Tsao, Bizhan Bandarchi-Chamkhaleh, Nhu-Ann Pham, Trevor Do, Martha MacLean, Rakesh Nayyar, Michael W. Tusche, Ur Metser, John J. Wright, Tak W. Mak and Lillian L. Siu
    Mol Cancer Ther March 1 2010 9 (3) 751-760; DOI:10.1158/1535-7163.MCT-09-0868

  • Research Articles
    IFN-β Restricts Tumor Growth and Sensitizes Alveolar Rhabdomyosarcoma to Ionizing Radiation
    Thomas L. Sims, Mackenzie McGee, Regan F. Williams, Adrianne L. Myers, Lorraine Tracey, J. Blair Hamner, Catherine Ng, Jianrong Wu, M. Waleed Gaber, Beth McCarville, Amit C. Nathwani and Andrew M. Davidoff
    Mol Cancer Ther March 1 2010 9 (3) 761-771; DOI:10.1158/1535-7163.MCT-09-0800

Letters to the Editor

  • Letters to the Editor
    ABL Alternative Splicing Is Quite Frequent in Normal Population - Letter
    Iñigo Santamaria, Ana S. Pitiot and Milagros Balbin
    Mol Cancer Ther March 1 2010 9 (3) 772-772; DOI:10.1158/1535-7163.MCT-09-0078

  • Letters to the Editor
    BCR-ABL1INS35 Is Not Uncommon in CML Patients and Is Related to Resistance and Sensitivity to Inhibitors in CML Treatment - Response
    Tai-Sung Lee, Wanlong Ma, Xi Zhang, Maher Albitar, Francis Giles, Jorge Cortes and Hagop Kantarjian
    Mol Cancer Ther March 1 2010 9 (3) 772-772; DOI:10.1158/1535-7163.MCT-09-1116

Correction

  • Correction
    Correction: Hormonal Regulation and Distinct Functions of Semaphorin-3B and Semaphorin-3F in Ovarian Cancer
    Mol Cancer Ther March 1 2010 9 (3) 774-775; DOI:10.1158/1535-7163.MCT-10-0171

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Molecular Cancer Therapeutics: 9 (3)
March 2010
Volume 9, Issue 3
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Issue Highlights

  • Identification of Expression Signatures Predictive of Sensitivity to the Bcl-2 Family Member Inhibitor ABT-263 in Small Cell Lung Carcinoma and Leukemia/Lymphoma Cell Lines

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Molecular Cancer Therapeutics
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