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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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Lapatinib is a potent small-molecule inhibitor of the ErbB2 and EGFR tyrosine kinases. In ErbB2 overexpressing breast cancer cell lines, lapatinib unexpectedly activated the antiapoptotic mediator RelA/NF-κB, which was shown to play a functional role in promoting the development of therapeutic resistance to lapatinib. Using immunohistochemical staining, it was found that tumor expression of phosphorylated RelA increased in a subset of ErbB2 overexpressing breast cancer patients who were treated with lapatinib monotherapy, which correlated with a poorer response to therapy. For more details, see article by Xia and colleagues on page 292.

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Molecular Cancer Therapeutics: 9 (2)
February 2010
Volume 9, Issue 2
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Issue Highlights

  • Resistance to ErbB2 Tyrosine Kinase Inhibitors in Breast Cancer Is Mediated by Calcium-Dependent Activation of RelA
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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