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Molecular Cancer Therapeutics
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Molecular Medicine in Practice

Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Isamu Okamoto, Hiroyasu Kaneda, Taroh Satoh, Wataru Okamoto, Masaki Miyazaki, Ryotaro Morinaga, Shinya Ueda, Masaaki Terashima, Asuka Tsuya, Akiko Sarashina, Koichi Konishi, Tokuzo Arao, Kazuto Nishio, Rolf Kaiser and Kazuhiko Nakagawa
Isamu Okamoto
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Hiroyasu Kaneda
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Tokuzo Arao
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Kazuto Nishio
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Rolf Kaiser
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Kazuhiko Nakagawa
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DOI: 10.1158/1535-7163.MCT-10-0379 Published October 2010
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Article Information

Volume 9, Issue 10, pp. 2825-2833

DOI 
https://doi.org/10.1158/1535-7163.MCT-10-0379
PubMed 
20688946

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received April 22, 2010
  • Revision received July 24, 2010
  • Accepted July 29, 2010
  • Published first August 5, 2010.

Article Versions

  • Previous version (August 5, 2010 - 08:02).
  • Previous version (September 21, 2010 - 08:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2010 American Association for Cancer Research.

Author Information

  1. Isamu Okamoto1,
  2. Hiroyasu Kaneda1,2,
  3. Taroh Satoh1,
  4. Wataru Okamoto1,
  5. Masaki Miyazaki1,
  6. Ryotaro Morinaga1,
  7. Shinya Ueda1,
  8. Masaaki Terashima1,
  9. Asuka Tsuya1,
  10. Akiko Sarashina3,
  11. Koichi Konishi3,
  12. Tokuzo Arao2,
  13. Kazuto Nishio2,
  14. Rolf Kaiser4 and
  15. Kazuhiko Nakagawa1
  1. Authors' Affiliations: Departments of 1Medical Oncology and 2Genome Biology, Kinki University School of Medicine, Osaka-Sayama, Japan; 3Nippon Boehringer Ingelheim Co. Ltd., Tokyo, Japan; and 4Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany
  1. Corresponding Author:
    Isamu Okamoto, Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan. Phone: 81-72-366-0221; Fax: 81-72-360-5000. E-mail: chi-okamoto{at}dotd.med.kindai.ac.jp
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Molecular Cancer Therapeutics: 9 (10)
October 2010
Volume 9, Issue 10
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Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors
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Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors
Isamu Okamoto, Hiroyasu Kaneda, Taroh Satoh, Wataru Okamoto, Masaki Miyazaki, Ryotaro Morinaga, Shinya Ueda, Masaaki Terashima, Asuka Tsuya, Akiko Sarashina, Koichi Konishi, Tokuzo Arao, Kazuto Nishio, Rolf Kaiser and Kazuhiko Nakagawa
Mol Cancer Ther October 1 2010 (9) (10) 2825-2833; DOI: 10.1158/1535-7163.MCT-10-0379

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Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors
Isamu Okamoto, Hiroyasu Kaneda, Taroh Satoh, Wataru Okamoto, Masaki Miyazaki, Ryotaro Morinaga, Shinya Ueda, Masaaki Terashima, Asuka Tsuya, Akiko Sarashina, Koichi Konishi, Tokuzo Arao, Kazuto Nishio, Rolf Kaiser and Kazuhiko Nakagawa
Mol Cancer Ther October 1 2010 (9) (10) 2825-2833; DOI: 10.1158/1535-7163.MCT-10-0379
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